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KMID : 0043320060290060484
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Archives of Pharmacal Research
2006 Volume.29 No. 6 p.484 ~ p.489
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The Effect of Luteolin-7-O-β-D-Glucuronopyranoside on Gastritis and Esophagitis in Rats
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Min Young-Sil
Bai Ki-Lyong
Yim Sung-Hyuk
Lee Young-Joo
Song Hyun-Ju
Kim Jin-Hak
Ham In-Hye
Whang Wan-Kyunn
Sohn Uy-Dong
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Abstract
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This study evaluated the inhibitory action of luteolin-7-O-β-D-glucuronopyranoside, luteolin which was isolated from Salix gilgiana leaves, and omeprazole on reflux esophagitis and gastritis in rats. Reflux esophagitis and gastritis were induced surgically and by the administration of indomethacin, respectively. The intraduodenal administration of luteolin-7-O-β-D-glucuronopyranoside decreased the ulcer index, injury area, gastric volume and acid output, and increased the gastric pH compared with luteolin. Luteolin-7-O-β-D-glucuronopyranoside significantly decreased the size of the gastric lesions that had been induced by exposing the gastric mucosa to indomethacin. The malondialdehyde content, which is the end product of lipid peroxidation, was increased significantly after inducing of reflux esophagitis. The malondialdehyde content was decreased by Luteolin-7-O-β-D-glucuronopyranoside but not luteolin or omeprazole. Luteolin-7-O-β-D-glucuronopyranoside has a more potent antioxidative effect than luteolin. Luteolin-7-O-β-D-glucuronopyranoside is a promising drug for the treatment of reflux esophagitis and gastritis.
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KEYWORD
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Reflux esophagitis, Lipid peroxidation, Gastric secretion, Free radical, Omeprazole, Luteolin, Luteolin-7-O-β-D-glucuronopyranoside, Rat
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